منابع مشابه
Modulation of sulfur mustard toxicity by arginine analogues and related nitric oxide synthase inhibitors in vitro.
The modulating effects of a series of arginine analogues and related nitric oxide synthase inhibitors against the toxicity of sulfur mustard (HD) in primary cultures of chick embryo forebrain neurons were examined. In addition to the previously identified protective compounds, D- and L-nitroarginine methyl ester, eight additional arginine analogues were shown to have significant, concentration-...
متن کاملSynthesis and Cytoprotective Efficacy Evaluation of New Drde-07 Analogues against Sulphur Mustard Toxicity
Sulfur mustard is well known as toxic Chemical warfare agent and on contact with skin it produces blisters as well as systemic toxicity. In this study we have evaluated the efficacy of few analogues of S-2(2-amino-ethylamino) ethyl phenyls sulphide (DRDE-07) and a known radioprotector amifostine against SM induced toxicity in mouse. We have selected seven newly synthesized analogues of DRDE-07 ...
متن کاملA Convenient Synthesis of Novel Phosphoramide Mustard Analogues of 2-Arylquinolone
A Convenient Synthesis of Novel Phosphoramide Mustard Analogues of 2-Arylquinolone Jinwei Yuan a , Xiaolan Chen a , Lingbo Qu a b , Shouren Zhang a , Jiansha Lu a & Yufen Zhao a c a Key Laboratory of Organic Chemistry and Chemical Biology, Henan Province, Department of Chemistry , Zhengzhou University , Zhengzhou, P. R. China b Henan University of Technology, Henan Province , Zhengzhou, P. R. C...
متن کاملIsophosphoramide mustard analogues as prodrugs for anticancer gene-directed enzyme-prodrug therapy (GDEPT).
Two types of prodrugs, benzyl analogues of isophosphoramide mustard (iPAM), activated by cytochrome P450, and acylthioethyl analogues, activated by esterases, were designed. In contrast to iPAM that hydrolyse rapidly, the examined compounds are stable in phosphate-buffered saline and Tris buffer. Benzyl analogues of iPAM are poor substrates for cytochrome P450, are not cytotoxic and posses no a...
متن کاملBackbone and benzoyl mustard carrying moiety modifies DNA interactions of distamycin analogues.
Alkylating distamycin derivative FCE-24517 (l) is the prototype of a novel class of alkylating agents. In the present study we have investigated the effect of further chemical modifications introduced in the alkylating distamycin-derived molecule with the aim of improving their ability to bind DNA. The new compound, MEN 10710 (II), has a four pyrrolecarboxamide backbone linked at its N-terminus...
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ژورنال
عنوان ژورنال: Pure and Applied Chemistry
سال: 2016
ISSN: 1365-3075,0033-4545
DOI: 10.1515/pac-2015-0604